Innovative medications like Mounjaro and Wegovy are transforming the weight loss journey for patients, offering proven results that can be life-changing. At PracticeRx, we combine these cutting-edge treatments with our concierge care model to ensure you achieve sustainable, long-term success. Unlike traditional clinics where decisions may be influenced by business constraints, we prioritize what’s best for you, offering both options under our transparent pricing model so you get the care that works for your goals and lifestyle.
Here’s a breakdown of the six key differences between Mounjaro (tirzepatide) and Wegovy (semaglutide) and how our approach ensures you get the right solution.
1. FDA-Approved Uses: Weight Loss vs. Diabetes Treatment
The primary difference between Wegovy and Mounjaro lies in their FDA approvals.
- Wegovy is FDA-approved for weight loss in adults and adolescents (12 and older) who are either obese or overweight with related conditions, like high blood pressure or cholesterol.
- Mounjaro is FDA-approved to treat Type 2 diabetes in adults, though its weight loss effects are well-documented.
At PracticeRx, we can prescribe both Wegovy and Mounjaro depending on your medical history and goals. If you’re focused on weight loss, we’ll evaluate whether Wegovy, Mounjaro, or Zepbound (the FDA-approved weight loss version of tirzepatide) is the best fit for your needs.
2. Eligibility: The Right Treatment for You
With Wegovy, eligibility is based on BMI:
- BMI of 30 or higher (obesity).
- BMI of 27 or higher (overweight) with at least one weight-related condition like hypertension or Type 2 diabetes.
Mounjaro is currently approved for patients with Type 2 diabetes, but it is increasingly used off-label for weight loss because of its remarkable effects.
At PracticeRx, we simplify the decision-making process. With no insurance barriers or hidden costs, our providers focus on your unique health profile and goals to determine the right treatment for you, whether that’s Wegovy, Mounjaro, or other evidence-based options.
3. How They Work: GLP-1 vs. Dual GIP/GLP-1 Action
Both medications mimic gut hormones that regulate appetite and blood sugar, but they target different pathways:
Wegovy works as a GLP-1 receptor agonist, helping to:
- Reduce appetite.
- Slow digestion to keep you feeling full.
- Improve blood sugar regulation.
Mounjaro acts as a dual GIP/GLP-1 receptor agonist, providing a two-hormone effect:
- GLP-1 for appetite suppression and digestion.
- GIP to enhance insulin production and metabolic efficiency.
This dual action often leads to greater weight loss, making Mounjaro particularly powerful for patients with obesity and metabolic concerns.
4. Weight Loss Results: Mounjaro Shows Greater Impact
Clinical studies show that both Wegovy and Mounjaro can deliver significant weight loss results, with Mounjaro demonstrating even greater reductions:
- Mounjaro: Patients lost an average of 15.7% of their body weight at the highest dose over 18 months, with nearly one-third achieving a 20% reduction.
- Wegovy: Clinical trials showed an average weight loss of 9.6% over 16 months.
At PracticeRx, we carefully evaluate which option will deliver the best results for you. Our providers monitor your progress closely, adjusting treatment as needed to ensure you’re achieving your weight loss goals effectively and safely.
5. Cardiovascular Benefits: Wegovy Leads the Way
If you have heart disease, Wegovy offers an additional benefit. In clinical trials, Wegovy reduced the risk of major cardiovascular events—like heart attacks and strokes—by 20%. For patients with cardiovascular concerns, this proven benefit can make Wegovy the preferred option.
While Mounjaro’s cardiovascular effects are still under investigation, ongoing studies show promising results. Our team at PracticeRx will guide you through the options and help you choose the medication that aligns best with your overall health needs.
6. The PracticeRx Advantage: Transparent Pricing and Comprehensive Care
The last one isn’t really a medication different, but a methodology difference. At PracticeRx, we take the confusion and business-driven decisions out of the weight loss process. With our transparent pricing model, you’ll always know exactly what you’re paying for, whether it’s Wegovy, Mounjaro, or other treatment options. We believe that cost should never interfere with getting the care that’s best for you.
Unlike traditional clinics that may simply prescribe medication and send you on your way, our concierge approach ensures ongoing, personalized support. This includes:
- Regular check-ins to monitor your progress.
- Immediate access to your provider via text, call, or video for questions or concerns.
- Comprehensive guidance on nutrition, exercise, and behavioral strategies to maximize your results.
