The PracticeRx Journal
Clinical insights,
plainly spoken.
MOTS-C: The Mitochondrial Peptide That's Changing GLP Plateau Management
MOTS-C is re-emerging from FDA research status as a legitimate tool for GLP-1 weight loss plateaus. Here's what the mechanism is, why it works where GLP-1 alone stalls, and what to expect.
Read Article →Insulin Resistance Without Obesity: The Hidden Driver of Metabolic Disease
You can be thin and metabolically broken. Here's how insulin resistance hides in lean bodies – and why your standard blood panel misses it.
Read Article →Why Your TSH Is 'Normal' But You Still Feel Like Garbage
Your doctor ran labs, told you everything looks fine, and sent you home. But you're exhausted, gaining weight, cold all the time, and can't think straight. Here's what they missed.
Read Article →Sermorelin vs. Ipamorelin: Which GHRH Peptide Actually Works Better
Both Sermorelin and Ipamorelin stimulate natural GH production – but they work differently and serve different clinical purposes. Here's how to choose.
Read Article →Peptide Sourcing: Why Your Peptides Might Not Be What You Think They Are
The peptide industry is rife with mislabeled, impure, and contaminated compounds. Here's how to identify pharmaceutical-grade peptides from sketchy research chemicals.
Read Article →Perimenopause Isn't a Hormone Deficiency – It's a Hormone Timing Problem
Most perimenopause is treated as estrogen deficiency. It's not. It's chaotic hormone fluctuation. Here's why that distinction changes everything about treatment.
Read Article →Cortisol Baseline Matters More Than Cortisol Spikes – Here's Why
Everyone talks about cortisol spikes. Nobody talks about baseline cortisol – which is actually what determines your metabolic fate.
Read Article →Sleep Isn't Recovery Time. It's When Your Hormones Do Their Best Work.
Poor sleep isn't just exhausting. It systematically dismantles your hormonal architecture — suppressing growth hormone, elevating cortisol, tanking testosterone, and blunting insulin sensitivity. You can't optimize your biology while treating sleep as optional.
Read Article →Depression Isn't Just Serotonin – It's a Metabolic and Hormonal Problem
SSRIs work for some people and fail for others. The reason is often metabolic or hormonal – not neurochemical. Here's what labs actually reveal.
Read Article →Anxiety as a Metabolic Disorder – And Why Your Doctor Missed It
Chronic anxiety is often not a psychological issue – it's your metabolism telling you something is broken. Here's what labs reveal.
Read Article →Cardiac Calcium Scoring: The Heart Test Most People Have Never Had
A cardiac calcium score is a 10-minute, low-radiation CT scan that quantifies your actual cardiovascular risk — far more precisely than cholesterol numbers alone.
Read Article →Testosterone Replacement for Women: What No One Is Telling You
Testosterone isn't a male hormone that women happen to produce. It's a critical driver of energy, libido, lean muscle, bone density, and cognitive function in women — and its decline often goes completely unaddressed.
Read Article →Peptide Stacking: How Combining Protocols Works — and Where People Get It Wrong
The peptide world has developed its own culture of stacking — combining multiple peptides into a single protocol. Sometimes the logic is excellent. Sometimes it's not. Here's a framework for thinking about combinations clearly.
Read Article →The 7-Day Provider: Why Healthcare That Stops at 5pm Isn't Healthcare
The most common medical events don't check your provider's office hours. Why same-day, 7-day access isn't a luxury — it's the minimum standard of competent care.
Read Article →Semaglutide Works. Here's Why It Stops Working — And What to Do About It
The 6-month plateau on GLP-1 therapy isn't a medication failure. It's the body adapting — which means the solution isn't more drug. It's understanding what's underneath it.
Read Article →The Gut-Brain Connection: Why Your Mental Health Lives in Your Microbiome
90% of serotonin is made in your gut. The microbiome isn't just about digestion — it's a primary driver of mood, anxiety, and cognitive function.
Read Article →The Wolverine Stack: BPC-157, TB-500, and the Art of Recovering Like You Mean It
The 'Wolverine Stack' has become shorthand in peptide circles for a specific combination of BPC-157 and TB-500. Here's an honest look at what it actually does, when it makes sense, and when you should pump the brakes.
Read Article →Your TSH Is 'Normal.' So Why Do You Still Feel Like Garbage?
The TSH range most labs use was never designed to tell you how you feel. It was designed to rule out crisis. There's a significant gap between those two things — and most people living in that gap have been told they're fine.
Read Article →What Your Annual Physical Isn't Measuring (And Probably Should Be)
The standard annual physical hasn't changed much in 30 years. It was designed for a population dying of acute infectious disease — not for people trying to prevent the chronic conditions that are actually killing us. Here's what's missing.
Read Article →The Hidden Cost of Reactive Medicine: What You're Actually Spending on the Broken System
The real cost of traditional healthcare isn't just your premiums. It's the urgent care visits, the ER copays, the lost work days, the specialist waitlists. Add it up and the math changes completely.
Read Article →Hashimoto's Thyroiditis: Why Standard Treatment Leaves So Many People Still Symptomatic
Millions of people with Hashimoto's are on levothyroxine with 'normal' TSH levels — and still exhausted, foggy, and gaining weight. Here's what's being missed.
Read Article →The Case for Full-Body MRI Screening Before You Have Symptoms
The most treatable version of almost any serious disease is the one you catch before you feel it. Full-body MRI screening is the most powerful tool available for identifying what's developing before it declares itself. Here's who it's for and what it actually shows.
Read Article →GHK-Cu: The Copper Peptide That Does More Than Your Skincare Routine Is Telling You
GHK-Cu shows up in every anti-aging serum on the market. But the clinical evidence points to something far more interesting — and far more systemic — than wrinkle reduction. Here's what the research actually says.
Read Article →Insulin Resistance: The Invisible Engine Behind Your Fatigue, Weight, and Brain Fog
You don't need a type 2 diabetes diagnosis to have a serious insulin problem. Insulin resistance runs silently for years, driving fatigue, abdominal weight, cognitive cloudiness, and hormonal disruption — and most standard labs won't catch it early enough.
Read Article →NAD+: The Most Overhyped and Underunderstood Molecule in Longevity Medicine
NAD+ has become the darling of the longevity world. It's also one of the most misrepresented. Here's a clear-eyed look at what it actually does, what the research supports, and why the delivery method matters more than most people realize.
Read Article →Anxiety Isn't Always What You Think It Is
Anxiety is often treated as a psychological problem that happens to have physical symptoms. The evidence points in a different direction — and it changes what treatment actually looks like.
Read Article →Direct Primary Care vs. Concierge Medicine: What's the Actual Difference?
The terms get used interchangeably. They're not the same thing. Understanding the distinction matters — because the model determines what level of care you're actually getting access to.
Read Article →Ipamorelin vs. Sermorelin: Which Growth Hormone Peptide Is Right for You?
Both ipamorelin and sermorelin stimulate growth hormone release — but they work differently and suit different clinical goals. Here's how to think about the choice.
Read Article →The Galleri Test: Multi-Cancer Early Detection and What It Actually Detects
The Galleri blood test screens for more than 50 cancer types simultaneously — most of which have no recommended conventional screening. Here's what the science shows.
Read Article →ADHD in Adults: What's Being Missed in Diagnosis and Management
Adult ADHD is dramatically underdiagnosed — and when it is diagnosed, it's often undertreated. Here's what a more complete clinical approach looks like.
Read Article →What to Expect in Your First Year as a PracticeRx Concierge Member
Most new members come in expecting a better version of their last doctor's office. What they get is fundamentally different. Here's what the first year actually looks like.
Read Article →Insulin Resistance: The Silent Driver Behind Most Metabolic Disease
Insulin resistance often develops a decade before type 2 diabetes appears — and it's driving weight gain, fatigue, brain fog, and hormonal dysfunction the entire time.
Read Article →BPC-157: What the Research Actually Says About This Peptide
BPC-157 has become one of the most talked-about peptides in functional medicine. We break down the science — and the hype — behind it.
Read Article →The Neuroscience of Anxiety: Why Willpower Alone Won't Fix It
Anxiety isn't a character flaw or a thinking problem. It's a neurobiological state — and understanding it that way changes everything about how you treat it.
Read Article →Full Body MRI: What It Finds, Who It's For, and Why We Offer It
A full body MRI can detect cancers, aneurysms, and organ abnormalities before they produce a single symptom. Here's what the scan covers — and who should consider it.
Read Article →The GLP-1 Plateau: Why Weight Loss Stalls on Semaglutide (And What to Do)
Most patients on GLP-1 therapy experience a plateau at some point. Understanding why — and how to break through it — is the difference between temporary results and lasting change.
Read Article →What Concierge Medicine Actually Costs You — and What It Saves
The upfront cost of concierge medicine is visible. The cost of not having it — in wasted time, delayed care, and compounding health problems — is hidden. Let's make it visible.
Read Article →Why Your Testosterone Lab Is 'Normal' and You Still Feel Like Hell
Standard reference ranges were built around population averages — not optimal function. Here's why 'normal' on paper doesn't mean you're optimized.
Read Article →